Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, there are several limitations that need to be addressed target more types. Natural killer (NK) a type innate represent unique biology surveillance. In particular, NK obtained from heathy donors can serve source for genetically engineered therapies. Therefore, NK-based therapies, including cells, CAR-NK and antibodies induce antibody-dependent cellular cytotoxicity emerged. With recent advances genetic engineering techniques, cell-based become promising approaches wide range cancers, viral infections, senescence. This review provides brief overview characteristics summarizes diseases could benefit addition, we discuss preclinical clinical investigations on adoptive transfer agents modulate activity.